Genetic complementation rescue system. Although RNAi knockdown is broadly applied in studying specific gene function in ESCs 21,26, eliminating the possibility of off-target effects of sequences ...

Featured peer-reviewed article: Combining CRISPR/Cas9 - mediated knockout with genetic complementation for in-depth mechanistic studies in human ES cells. BioTechniques is part of Taylor & Francis ...

The inner nuclear membrane of eukaryotic cells defines many aspects of gene expression and chromatin organization. ... We have leveraged the power of yeast genomics and split-GFP complementation to ...

Background: Inactivating genomic alterations (GA) of FANCC gene are associated with genomic instability, DNA cross-linking, and homologous DNA repair deficiency (HRD).FANCC GA are most frequently ...