A guardian molecule ensures that liver cells do not lose their identity. This has been discovered by researchers from the ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

Cancer models developed with 3D bioprinting technology allow for rapid evaluation of individual drug responses.

Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells orchestrate an array of changes including degradation of the normal ECM of liver ...

When a tumor develops, it creates a structure around itself called the tumor stroma, within which blood and lymphatic vessels ...

Despite the established links between inflammation and cancer development, the effects of inflammatory signaling on cancer ...

LATS1/2-inactivation and consequent nuclear YAP/TAZ hyperactivation in the mammary epithelium drives the development of a pro ...

Changes to the intermediate filament (IF) protein, vimentin, were found to promote tumor growth by increasing cancer stemness in an oestrogen independent manner. Targeting vimentin and/or the long ...

Laboratory for Research on the Structure of Matter (LRSM), University of Pennsylvania, Philadelphia, United States ...

The program has shown strong ... Outside-in Signaling Shows a Route Into Cancer Cells Feb. 4, 2025 — A new study shows how an anticancer drug triggers an 'outside in' signal that gets it sucked ...

az.vub.ac.be Accumulating evidence suggests that stellate cells are involved in the regulation of the liver microcirculation and portal hypertension. Activated hepatic stellate cells have the ...