Solid tumors that originate in the deep internal organs, such as the pancreas, liver, and ovary, have poor prognoses due to the difficulties of diagnosing ...

Variations in tumor biology from patient to patient combined ... oxygen concentration, cell type, and the availability of a 3D microenvironment (2D vs. 3D) on drug metabolism and response to two ...

med.osaka-cu.ac.jp Background MicroRNAs (miRNAs) are important in hepatic pathophysiology and the development of liver cancer. Objective To explore ... mouse livers from two fibrosis models and ...

In lab-dish experiments, the sEVs specifically move towards and bind to DR5 and quickly killed cancer cell types that have high levels of DR5 expression, including melanoma, liver ... where the ...

9 Affiliated Cancer ... cells, and myofibroblasts also create a metabolically active state in the microenvironment to help the oCRC growth. Overall, our results have provided an important insight into ...

Engineered immune cells called CAR-T cells are used in the treatment of cancer. Researchers from Uppsala University have now ...

A guardian molecule ensures that liver cells do not lose their identity. This has been discovered by researchers from the ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

Cancer models developed with 3D bioprinting technology allow for rapid evaluation of individual drug responses.

Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells orchestrate an array of changes including degradation of the normal ECM of liver ...