The CD2-CD58 axis is associated with the regulation of autoimmune diseases, immune evasion of tumors, antiviral responses, and immune rejection, and targeted therapies for this have been developed.

The interaction between CD2 and CD58 is critical for forming the immunological synapse, which is pivotal in immune cell activation and adhesion, as well as signaling in both immune and target cells.

“By doing that, this small protein is able to cross-link target cells and effector cells in a way that forces the creation of an immune synapse, activates the T cell and then kills the target ...

Immunological synapse (IS) formation is a key part of developing and sustaining immune responses against cancer and is necessary for T cells and NK cells to eliminate tumor cells. This webinar will ...

When naive T cells encounter antigen-presenting cells (APCs), membrane and cytoplasmic molecules rearrange at the T cell–APC contact area to form the immune synapse. Finetti et al. now reveal an ...

Cell-to-cell interactions contribution to intercellular communication: A large portion of intercellular communication in the immune system is mediated by transient, structurally dynamic contacts ...

A study published in Science Advances shares new insights into how two of the most common types of chimeric antigen receptor (CAR) T cells kill cancer. Investigators from Baylor College of ...