Institute of Molecular Medicine (IMM), Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, State Key Laboratory of Systems Medicine for Cancer, Department of Pharmacy, Renji Hospital, ...

In this study, the effects of introducing leucine residues into the hydrophobic face of an amphipathic helix on the intermolecular interactions of peptides were evaluated. We focused on BKBL-20, a ...

Because of their poor hepatic catabolism, circulating BCAAs, in particular, leucine, act as signaling molecules and nutritional sensors. They promote protein synthesis, cellular metabolism, and cell ...

This month's cover highlights the article EGFR controls transcriptional and metabolic rewiring in KRASG12D colorectal cancer by Dana Krauß, Maria Sibilia and colleagues. The tumor-intrinsic role of ...