Diffuse large B-cell lymphoma (DLBCL) is curable in 60% of patients treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). MYC translocations, with or without ...

The activation of LDHA and TFRC, target genes of both MYC and HIF, further contributes to the Warburg effect and the proliferative phenotype of hypoxic cancer cells that contain an activated MYC ...

The tumour suppressor FBW7 is the substrate recognition component of the SCF-type ubiquitin ligase that degrades several proto-oncogenes, including MYC and cyclin E. How do the numerous cancer ...

Stanford University's Hoover Institution houses a collection documenting World War II Nazi Germany. This conversation focused on the post-war hunt for top-level Nazis who fled Germany. Historian ...

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In the regulation of cancer cell proliferation, histone Kla affects tumor growth through CDK1, CCNE1, AURK, Cyclin B1, CCR7, IGFBP6, DVOL1, and SDC1, whereas LDHA‐Kla influences breast cancer ...

Targeting cancer-associated fibroblast metabolism or histone lactylation in pancreatic cancer cells to reverse epigenetic remodeling induced by lactate accumulation in the tumor microenvironment are ...