Antibody–siRNA conjugates (ARCs) are a type of promising drug modalities for cancer therapy. However, initial reports of ARCs present the gene knockdown effect only in limited tissues (e.g., muscles) ...

Glycosylated (pro)renin is also taken up by the insulin-like growth factor II or mannose receptor and is activated within cardiomyocytes.

The enzyme in Nexviazyme has 15-fold more mannose-6- phosphate (M6P) residues per molecule than alglucosidase alfa, which according to Sanofi scientists increases enzyme uptake in targeted tissues ...

BYLieve showed activity of alpelisib plus fulvestrant with manageable toxicity in patients with PIK3CA-mutated, hormone receptor-positive, HER2-negative advanced breast cancer, after progression on a ...