JCR today announced that it achieved the enrollment of the target number of participants in the global Phase III clinical trial of JR-141.

Mannose-6-phosphate-receptor-independent sorting mechanisms have recently been described and are probably also relevant to NK-cell lytic-granule maturation 129.

Published: 29 June 1957 Formation of Erythrose-4-phosphate and Acetyl Phosphate by a Phosphorolytic Cleavage of Fructose-6-phosphate M. SCHRAMM & E. RACKER Nature 179, 1349–1350 (1957) Cite this ...

Now Approved in Japan for Adults with Late-onset Pompe Disease (LOPD)PRINCETON, N.J., and TOKYO, June 25, 2025 (GLOBE NEWSWIRE) -- Amicus Therapeutics (Nasdaq: FOLD) today announced that Japan's ...

Antibody–siRNA conjugates (ARCs) are a type of promising drug modalities for cancer therapy. However, initial reports of ARCs present the gene knockdown effect only in limited tissues (e.g., muscles) ...

3-Hexulose-6-phosphate synthase, a key enzyme in the ribulose monophosphate pathway, plays a central role in formaldehyde assimilation and detoxification, offering great potential for third-generation ...

The enzyme in Nexviazyme has 15-fold more mannose-6- phosphate (M6P) residues per molecule than alglucosidase alfa, which according to Sanofi scientists increases enzyme uptake in targeted tissues ...

Tocilizumab, a novel IL-6R inhibitor, may be beneficial for the treatment of RA in patients who do not respond to methotrexate or disease-modifying antirheumatic drugs.

Adenosine Pathway Modulation in RA Several studies have shown the relationship between the adenosine pathway and joint inflammation in RA in vitro and in vivo. [84] A 1, A 2A, A 2B and A 3 ARs ...

The best CBD gummies make trying CBD safe and convenient. Find the best CBD gummies for stress, relaxation, and more here.

Research shows that CBD may help some people manage anxiety. Healthline editors have tested and chosen these CBD oils as their favorites. See if one is right for you.

In active SLE, CRP levels are disproportionally low for increased IL-6 levels. While a molecular explanation is lacking, these low CRP levels have been found associated with increased type I ...