Interestingly, this process seemed to operate independently of NFAT5, suggesting multiple activation pathways are involved in the microglial response to hyperosmotic stress. Additionally ...

This makes it a challenging but exciting therapeutic target." Microglial activation is a hallmark of AD, and CD2AP plays a key role in modulating microglial responses to amyloid plaques.

Scientists have linked MARCKS to activation of microglia by Aβ (Hasegawa et al., 2001). FGFR3 is a receptor for FGF2, which is churned out by neurons in response to Aβ oligomers, summoning microglia ...

In a plenary session at the annual American Academy of Neurology meeting, Paul Edison, MD, PhD, of Imperial College London in ...

Tiziana Life Sciences (TLSA) announced dosing of new patients at Yale MS Center which is participating in our multicenter Phase 2 clinical ...

SHENZHEN -- Chinese scientists have, for the first time, confirmed the existence of microglia in the peripheral nervous ...

This Phase 2 trial aims to assess the safety, tolerability, and foralumab’s effect on microglial activation in patients with na-SPMS. Intranasal foralumab offers a novel approach to potentially ...

A new study reveals that inflammation during pregnancy may impair neurodevelopment in infants by reducing CD11c-positive microglia—key immune cells that support brain myelination.