Our previous research demonstrates that the CD40 signaling is critically involved in microglia-related immune responses in the brain. For example, it is well known that the activation of the ...

Here authors demonstrate a role for nonapoptotic caspase-3 activation in neurons with elevated activity, in the promotion of C1q deposition and synaptic phagocytosis by microglia. Microglia and ...

Additionally, the study explores mechanisms underlying microglial activation and its effects on neuronal health, focusing on the interplay between inflammatory pathways and mitochondrial dynamics.

Interestingly, this process seemed to operate independently of NFAT5, suggesting multiple activation pathways are involved in the microglial response to hyperosmotic stress. Additionally ...

Specifically, the toll-like receptor 4 appears to be a site at which drugs of abuse activate microglia. Toll-like receptor 4 activation consequently produces an innate immune response in the brain ...

Scientists provide new evidence that preventing brain inflammation is a promising approach for the treatment of Alzheimer's disease. Their findings, based on studies in cell culture, mice and tissue ...

Researchers have unveiled transformative insights into the relationship between inflammation and depression, a finding that ...

The paper, published Wednesday in Science Translational Medicine, shows the potential of inhaled xenon to activate the brain’s immune cells, called microglia, to break down plaques that are a ha ...

Microglia, the brain's immune cells, exhibit altered gene expression and a weakened immune response as they age, potentially contributing to neurological disorders like Alzheimer's and Parkinson's.

Tiziana Life Sciences, Ltd. (Nasdaq: TLSA) (“Tiziana” or the “Company”), a biotechnology company developing breakthrough immunomodulation therapies with its lead development candidate, intranasal ...