Most of these variants map to noncoding genomic regions ... Parking a giant CRISPR repressor on DNA is helpful for discovering causal variants, but it is not realistic in a biological sense. STING-seq ...

The researchers studied resistance variants found in the non-coding genome, which makes up 98% of DNA and does not contain genes. Previous attempts to identify resistance mechanisms to ...

Long noncoding RNAs (lncRNAs) are RNAs longer than 200 nucleotides that do not contain any open reading frames greater than 300 nucleotides (100 codons). The DNA sequences they’re transcribed from can ...

Swiss start-up Haya Therapeutics has formed a partnership with Eli Lilly – worth up to $1 billion – to look for new therapies for obesity in non-coding DNA. The biotech focuses on trawling the ...

The involvement of noncoding mRNAs in many regulatory processes ... that an "RNA world" may have preceded the evolution of DNA and proteins (Gilbert, 1986). Small interfering RNAs (siRNAs ...

First, both coding and noncoding regions of DNA are transcribed into mRNA. Some regions are removed (introns) during initial mRNA processing. The remaining exons are then spliced together ...

It also learned how DNA mutations affect proteins, RNA, and overall health, shining light on “non-coding” regions, in particular. These mysterious sections of DNA don’t make proteins but often control ...

It’s time to shine a light on the next wave of drug discovery.

Another area of interest is the noncoding or epigenetic regulation of development. We are developing methods to uncover the underlying regulatory DNA sequences by focusing on developmental enhancers.