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Cancer does not develop overnight. It can take decades for cancer‐promoting changes in the genome to eventually lead to the ...
Conclusions Our results provide novel evidence that hypomethylation of specific LINE-1 elements permits inadvertent activation of methylation-silenced MET , RAB3IP and CHRM3 proto-oncogenes in CRC ...
Among the class 1 oncogenes that promote cell growth, we find mutations in the intracellular signaling protein Ras (20% of patients) and activation of tyrosine kinases (40% of patients), such as ...
The researchers' recently published study describes a way to re-activate apoptosis in mutated cells, which would amount to forcing cancer to self-destruct through a bioengineered, bonding molecule.
Proto-oncogenes regulate cell growth; mutations convert them to oncogenes, leading to cancer by disrupting normal cell division processes.
Delphia Therapeutics is a biotechnology company pioneering activation lethality, a new area of cancer therapeutics that target cancer's surprising vulnerability to oncogene overactivation.
Whether TMPRSS2-ERG fusion and TP53 gene alteration coordinately promote prostate cancer (PCa) remains unclear. Here we demonstrate that TMPRSS2-ERG fusion and TP53 mutation / deletion co-occur in PCa ...
Immunotherapy, a treatment that increases the survival of cancer patients to the point of remission of the disease, can also have the opposite effect. In some patients, immune checkpoint blockade ...
New research on cancer-causing genetic mutations may lead to improved ways of predicting and treating the disease.
Researchers have zeroed in on specific mechanisms that activate oncogenes, which are altered genes that can cause normal cells to become cancer cells. This work advances the ability to predict and ...
Oncogenes are mutated genes that (often along with tumor suppressor genes) can lead to cancer. Learn about how they work, examples, and types.
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