Researchers at the German Cancer Research Center (DKFZ) have now developed a method that allows for the first time to ...

Proto-oncogene mutations are found in 15% to 20% of unselected human tumors. 7 In humans, point mutations are linked with a single amino acid change within the protein, which causes tumor ...

Scientists at Fox Chase Cancer Center have identified a mutation in a common oncogene—a gene that can cause cancer—that may play an important role in colon cancer. Researchers also showed how ...

High-throughput oncogene mutation detection in human cancers by mass spectrometry-based genotyping Peer-Reviewed Publication. American Association for Cancer Research ...

Oncogene mutation hijacks splicing process to promote growth and survival Date: May 31, 2013 Source: University of California, San Diego Health Sciences ...

For the first time, an oncogenic somatic mutation at amino acid 918 in the rearranged during transfection protein has been identified in small cell lung cancer tumors and enforced expression of ...

In addition to establishing FOXA1 as a true oncogenic driver in prostate cancer, their findings reveal the distinct ways that each class of FOXA1 mutation operates. Firstly, Class 1 mutations, ...

(A) Oncogene mutations were grouped together when they occurred within a given gene (e.g., 'KRAS' for all mutations in 'KRAS') or in the same functional domain of the encoded protein (e.g ...

Kirsten ratsarcoma viral oncogene homolog (KRAS) mutations occur in ~20%–30% of patients with NSCLC. Recently, several small molecules including sotorasib (AMG510), adagrasib (MRTX-849) have ...

Synonymous mutations can also influence the speed of translation because the precise codon used determines how quickly it’s translated by ribosomes. For instance, one 2016 study reported that a ...

Proto-oncogenes: One genetic mutation that can lead to multiple myeloma is a change in proto-oncogenes, which control how cells grow and divide. When these genes mutate, they are then called ...