Oncolytic virus therapy is not a new discovery, but it may now be positioned as the next major breakthrough in cancer treatment following the success of checkpoint inhibitors in immunotherapy. An ...

Scientists have identified dozens of human proteins that SARS-CoV-2, the virus that causes COVID-19, depends on to replicate ...

Human papillomaviruses, or HPVs, can cause dangerous infections in the skin and mucous membranes and may lead to cancer.

One-in-six patients treated with the modified virus as part of a clinical trial saw their tumors disappear completely.

Here, the authors combine oncolytic virus (OV) engineering and reprogramming of the IL-18 pathway, showing that armed OVs expressing a decoy-resistant IL-18 elicit anti-tumor immunity and long ...

Coincident with and underlying the unchecked viral replication, filoviruses deceive and dysregulate both innate and adaptive immune responses.