The researchers identified the structure of this machine, the mitochondrial pyruvate carrier (MPC), and 50 years since its discovery, have shown how it operates like the lock on a canal to transport ...

When they are broken down inside our cells they produce pyruvate, but to get the most out of this molecule it needs to be transferred inside the cell's powerhouses, the mitochondria. There ...

Proliferating cells, in particular tumor cells, are characterized by a high amount of the dimeric form of the pyruvate kinase isoenzyme type M2 (Tumor M2-PK). Tumor M2-PK can be determined in EDTA ...

Etavopivat is an oral selective pyruvate kinase-R activator that has been awarded fast track and orphan status by the FDA, and along with a phase 2/3 HIBISCUS trial in SCD is also in a follow-up ...

Mitochondria produce energy-rich molecules known as ATP, which power everything we do. But mitochondria are picky: they need a specific molecule called pyruvate, created from sugars, to make the ...

Avoid the stress of overpaying for a stock or missing an opportunity by using the right tools and insights to evaluate Rocket Pharmaceuticals, Inc. before investing. In this article, we go over a few ...

Figure 4 – figure supplement 1. Loss of Gls in rod photoreceptors alters the expression of retinal metabolism-related genes qRT-PCR analysis of genes related to (A) glycolysis and pyruvate metabolism ...

From Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville Campus, Victoria, Australia (R.H.R.) Division of Endocrinology and Metabolism (E.D.A.), ...