In this study, an up-regulation of serine/arginine-rich splicing factor 7 (SRSF7) was identified in lung fibroblasts derived from IPF patients and a bleomycin (BLM)-induced mouse model, and further ...

Both a wild-type mouse M2 and a phosphotyrosine-binding mutant M2KE can rescue pyruvate kinase activity and glycolysis in knockdown cells.

Moreover, Pyrukynd has already been approved for pyruvate kinase deficiency and is expected to receive FDA approval for thalassemia and potentially EMA approval in 2026.

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

The human pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate with formation of acetyl-CoA, CO 2, and NADH (H +) and occupies a key position at the intersection of ...

Cerebral blood flow, oxygen, glucose, lactate, and pyruvate metabolism were measured in 13 subjects with completed stroke. Cerebral blood flow and oxygen consumption were reduced, glucose consumption ...