More information: Haihua Zhang et al, ING5 inhibits aerobic glycolysis of lung cancer cells by promoting TIE1-mediated phosphorylation of pyruvate dehydrogenase kinase 1 at Y163, Frontiers of ...

There is some evidence to suggest glycolytic activity is increased with age, with an increase in pyruvate kinase activity ... is not only due to tissue hypoxia or anaerobic glycolysis but also due to ...

The researchers identified the structure of this machine, the mitochondrial pyruvate carrier (MPC), and 50 years since its discovery, have shown how it operates like the lock on a canal to transport ...

When they are broken down inside our cells they produce pyruvate, but to get the most out of this molecule it needs to be transferred inside the cell's powerhouses, the mitochondria. There ...

Proliferating cells, in particular tumor cells, are characterized by a high amount of the dimeric form of the pyruvate kinase isoenzyme type M2 (Tumor M2-PK). Tumor M2-PK can be determined in EDTA ...

Researchers from Tohoku University challenged the mouse brain with a metabolic load induced by epileptic seizures, and observed fluctuations in blood volume, astrocytic pyruvate, and neuronal ATP.

Jackson, Mississippi, March 28, 2025 (GLOBE NEWSWIRE) -- For some of the most sought-after and freshest perspectives on weight management, cellular energy production, and how a revolutionary ...

Etavopivat is an oral selective pyruvate kinase-R activator that has been awarded fast track and orphan status by the FDA, and along with a phase 2/3 HIBISCUS trial in SCD is also in a follow-up ...

Mitochondria produce energy-rich molecules known as ATP, which power everything we do. But mitochondria are picky: they need a specific molecule called pyruvate, created from sugars, to make the ...