The authors describe the abnormal contractile function and cellular electrophysiology in an iPSC model of atrial myocytes with a titin missense variant. They provide contractility data by sarcomere ...
(A) Location of the T23756I at Ig139 domain in the A-band of titin. (B) Allele frequencies of T3265I between ... Supplementary Figure 3: Contractility and sarcomere organization of TTN-T32756I ...
Key proteins of normal cardiac sarcomere such as myosin 6 (MYH6), myosin 7 (MYH7), actin alpha cardiac muscle (ACTC1) and titin (TTN) were concordantly found markedly decreased in severe anthracycline ...
Three modules of correlated proteins in HFpEF that correlated with left ventricular hypertrophy and right ventricular load related to (1) proteasome; (2) fuel metabolism; and (3) protein translation, ...
Shenzhen Key Laboratory of Smart Sensing and Intelligent Systems, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P.R. China University of Chinese Academy of ...
This review explores the molecular mechanisms underpinning HCM and the rapidly advancing field of HCM translational research, including gene therapy and small-molecule interventions targeting ...
Cardiovascular disease is the number one killer worldwide, with myocardial infarction (MI) responsible for approximately 1 in 6 deaths. The lack of endogenous regenerative capacity, added to the ...
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