Antibody–siRNA conjugates (ARCs) are a type of promising drug modalities for cancer therapy. However, initial reports of ARCs present the gene knockdown effect only in limited tissues (e.g., muscles) ...

Membrane proteins are proteins found in cell membranes, either at the surface or on intracellular organelles. Integral membrane proteins such as receptors and ion channels span the membrane ...

In the process of synaptic transmission, vesicle trafficking refers to the formation, intracellular movement and exocyotosis and endocytosis of synaptic vesicles.

Intracellular chloride ( [Cl −] i) and pH (pH i) are fundamental regulators of neuronal excitability. They exert wide-ranging effects on synaptic signaling and plasticity and on development and ...