In a bid to better understand how cancer cells power their explosive growth and spread, scientists at Johns Hopkins Medicine say they have shed new light on the location and function of power ...

Energy-generating waves on the membranes of cancer cells may help to fuel disease progression. Disrupting the process could slow or halt cancer metastasis. Higher levels of the enzymatic waves ...

The scientists then found a 25% decrease in ATP, suggesting that cancer cells largely depend on these waves to fuel and execute their daily energy-intensive activities.

With this approach, we can now screen large chemical libraries, containing millions of compounds, to find molecules that can inhibit specific polyamine synthesis enzymes.

The shorter prototypes, however, are simpler relative to the “intact” construct (in terms of sequence complexity and number of residues) and, thus, more plausible representatives of early enzymes.

This paper addresses a fundamental question: Can natural chaperones fold mirror-image proteins? Mirror-image proteins (composed of d -amino acids) are only accessible by chemical synthesis, but are ...

We have assayed the nucleotidyl transfer reaction catalyzed by DNA ligase from bacteriophage T4, a Mg 2+ - and ATP-dependent enzyme that seals nicks in dsDNA (9). In the first step of catalysis, which ...

This study explores ligand-driven conformational changes in adenylate kinase (AK), which is known for its open-to-close conformational transitions upon ligand binding and release. By utilizing string ...

Services The Microscopy and Cell Analysis Core provides three complimentary high-end services to research and clinical investigators. Electron microscopy The core has both scanning electron ...