This study shows that small cell subpopulations experience transient, high-intensity mutational bursts, greatly increasing ...

Picture a living cell as if it were a city. If you were the urban planner for this (very little, very alive) city, one of the ...

The unfolded protein response (UPR) is a crucial signaling network that preserves endoplasmic reticulum (ER) homeostasis, impacting both health and disease. When ER stress occurs, often due to an ...

Many of the staining agents or markers are not applicable to live cell imaging as they are toxic. In this paper, we report theoretical and experimental results from quantitative phase imaging of yeast ...

Centromeres, specialized regions located at the center of chromosomes, are critical for ensuring proper cell division. During ...

Researchers have captured a time-resolved video of a protein interaction essential to healthy brain development.

We show that yeast Hsp90 (Hsp82) and Hsp70 (Ssa1 ... including many kinases and steroid hormone receptors involved in cell-signaling pathways. Hsp90 chaperone activity requires collaboration with a ...

Endogenous intracellular allosteric modulators of GPCRs remain largely unexplored, with limited binding and phenotype data available. This gap arises from the lack of robust computational methods for ...

Scientists produce human DNase1 in yeast for the first time, opening doors to wider clinical use and easier manufacturing.

The protein DNase1 is one of the oldest biological agents in history. It has been on the market since 1958 and is now used, ...

The protein DNase1 is one of the oldest biological agents in history: It has been on the market since 1958 and is now used, among other things, to treat cystic fibrosis.

South African Grape and Wine Research Institute, Department of Viticulture and Oenology, Stellenbosch University, Private Bag X1, Matieland 7602, South Africa Department of Agronomy, Food, Natural ...