A series of 2-amino-5-arylthiobenzonitriles (1) was found to be active against HIV-1. Structural modifications led to the sulfoxides (2) and sulfones (3). The sulfoxides generally showed antiviral ...

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Replacement of the pyridine core of antimalarial 3,5-diaryl-2-aminopyridines led to the identification of a novel series of pyrazine analogues with potent oral antimalarial activity. However, other ...

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Dry state oligomerization of nucleoside 2′,3′-cyclic phosphates catalyzed by amino acids. Credit: Nature Communications (2025). DOI: 10.1038/s41467-025-60359-3 ...