Pathophysiology, current treatments, and future directions. Journal of Medicinal and Pharmaceutical Chemistry Research, 2024, 6(7), 944-952 Joyce C. Hollander-Rodriguez and James F. Calvert.

THE role of lipids as predictors of coronary heart disease has become of considerable interest during the past two decades. Many individual lipids, such as the serum cholesterol, phospholipid and ...

When this happens, it is called atherosclerosis. Clogged or blocked arteries can stop fresh blood from reaching parts of the body, which can put a person at risk of a heart attack, heart failure ...

Ultimately, these effects of ImP accelerate the progression of atherosclerosis, thereby linking it to the pathophysiology of ACVD (Graphic Abstract). Our studies indicate that ImP exerts deleterious ...

Circulating ceramides have recently emerged as an independent risk factor for atherosclerotic cardiovascular disease, but precisely how they contribute to the pathogenesis of atherosclerosis ...

Coronary atherosclerosis is a chronic condition characterised by the development of an atherosclerotic plaque in the inner layer of the coronary artery, mainly associated with cholesterol accumulation ...

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States ...

Oxidative stress, particularly, in the heart, is critical in different conditions, including hypertension, heart failure, ...

Features of vascular aging—pathophysiology and relationship with coronary ... However, it is still unclear what drives the relationship between arterial stiffness and atherosclerosis (36). To further ...

Moreover, the difference in the atherosclerosis pathogenesis between various species was not fully investigated. Atherosclerosis was believed to develop similarly in humans and model animals, which, ...

Here, we discuss the molecular effects of LDL on monocyte recruitment to the arterial wall as a crucial step in the pathogenesis of atherosclerosis. Figure 1. Modification of low-density lipoproteins ...