In 1981, the first azole antifungal, the diazole ketoconazole, was introduced to the market; then, in the early 1990s the first-generation triazoles, fluconazole and itraconazole, became available.

Antifungal azoles are also widely used as a ... Instead, they found that azole-induced reduction of ergosterol increases the activity of cellular mitochondria, the "powerhouse" of the cell ...

Fluconazole, a very safe and effective azole antifungal, requires a much higher dose in children (12 mg/kg/day) compared with adult patients. In addition, the neonatal field is exploring ...

Neurotoxicity with concomitant vincristine; reserve azole antifungals for those who have no alternative treatment options. Prolonged hypnotic and sedative effects with concomitant midazolam or ...

such as with non-azole antifungals in models of azole-resistant candidiasis. Promedixinc focuses on detecting sepsis at the early stages through noninvasive optical circulatory dysfunction monitoring.

Potentiated by CYP3A4 inhibitors (eg, macrolides, azole antifungals, protease inhibitors). Antagonized by CYP3A4 inducers (eg, rifampin, carbamazepine, phenytoin). May antagonize diuretics ...

Potent inhibitors of both CYP3A4 and P-gp include azole antifungals (e.g., ketoconazole, itraconazole, voriconazole and posaconazole) and protease inhibitors (e.g., atanazavir). INR: International ...