Cover: The HIV protease inhibitor Nelfinavir promotes the activation of the kinase eEF2K. This triggers the phosphorylation of the translation factor eEF2 thereby reducing the rates of protein ...

Their grandmother and two aunts had breast cancer, and their father tested positive for the BRCA gene, which increases the risk of developing the disease. "We were unlucky in that both of us got ...

Critical Bitcoin legislation was introduced last week & it needs our support The Blockchain Regulatory Certainty Act (BRCA) by @GOPMajorityWhip and @RitchieTorres protects self-custody developers ...

The trial’s primary endpoint is rPFS. Among patients with BRCA alterations, the combination reduced the risk of radiographic progression or death by 48% and delayed symptom progression by 56%. In the ...

The risk of disease progression decreased by 37% in all patients treated with the PARP inhibitor and by 48% in the subgroup with BRCA1/2 mutations. Niraparib also increased time to symptom ...

The uncertainty lies in a group of patients without BRCA mutations. Previously, Zejula’s addition to Zytiga and prednisone showed a progression-free survival benefit in HRR-mutated mCRPC in the ...

Of the patients, more than half (55.6%) had alterations in the BRCA1 or BRCA2 genes. Most of the patients also had tumors with aggressive features, such as cancer that had spread to the lymph nodes or ...

Designed to fly at over 100,000 feet and hit Mach 4+, the DSB-LK could have been the deadliest aircraft of the Cold War. It combined speed, stealth, and raw power in a way that alarmed U.S ...

TNBC is more common in Black patients and those with a BRCA1 gene mutation. About 40% of TNBC tumors express the programmed death ligand 1 (PD-L1) protein. For PD-L1-positive locally advanced and ...

The research, published in Nature Communications, suggests this preemptive, two-part approach could be the most effective plan of treatment for early-stage breast cancer linked to BRCA1 and BRCA2 ...