Hepatic synthesis of bile acids is the primary pathway for cholesterol catabolism. The cholesterol 7α-hydroxylase enzyme (encoded by CYP7A1) represents the rate-limiting step of the multi ...

Combining a statin with a bile acid sequestrant, fibrate or ezetimibe can help achieve lipid goals, and a bile acid sequestrant has the unique ability to reduce LDL-C, while improving glycemic ...

Bacteria naturally present in the human intestine (known as the gut microbiota) can transform cholesterol-derived bile acids ...

Sometimes, managing high cholesterol levels may require taking medication like Lipitor. But an expert says that this may have an unexpected effect on your poop.

but it appears that it binds to cholesterol and bile acids in the intestine, making it unavailable for absorption. Then, when the liver needs to replace the bile acids that went out with the fiber ...

The liver then uses some of this cholesterol to produce bile acids, hormones, and other essential compounds. Excess cholesterol is packaged into lipoproteins like Low-Density Lipoprotein (LDL ...

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Figure 1: Steady-state mRNA levels of genes that are regulated by Tcf1. Figure 4: Bile acid concentrations are increased in the serum, stool and urine of Tcf1 −/− mice. Figure 5: Tcf1 is a ...

Cholesterol helps your liver create fat-dissolving bile acids, which help with digestion. And it's a crucial building block in every cell membrane. Cholesterol doesn't dissolve in blood -- so it ...

Ctexli significantly reduced levels of two atypical cholesterol metabolites usually elevated in patients with cerebrotendinous xanthomatosis (CTX) compared to the placebo. Common side effects of ...