Here, we explored how NMDARs signal in tLTD. We found that, regardless of frequency, L5 PC→PC tLTD relies on the non-ionotropic preNMDAR signaling pathway mediated by JNK2, which helps to resolve the ...

The anaphylatoxin C3a mediates pro-inflammatory and chemotactic functions through the G protein-coupled receptor C3aR. While the active structure of the C3a-C3aR-G i complex has been determined, the ...

Receptor pharmacology is the study of the interactions of receptors with drugs/pharmaceuticals and other xenobiotics. A basic tenet of receptor pharmacology is that a drug’s effect is directly ...

Many people claim that cannabidiol (CBD) helps them manage their anxiety. In recent years, CBD has been widely studied for its potential benefits to help with numerous conditions, including ...

Brian Kelly and the LSU Tigers wrapped up Day 10 of Spring Camp on Thursday morning with the program getting back out on the practice fields in Baton Rouge. Kelly's crew continues working through ...

The acquisition will add SKNY-1 to Mira’s pipeline. Mira said the oral candidate is “designed to interact with cannabinoid receptors CB1 and CB2 pathways.” Interest in treating smoking and ...

Agonists of the type 1 cannabinoid receptor (CB1) show promise as alternative analgesics but are still limited by side effects and tolerance. Reporting in Nature, Rangari et al. apply computation ...

Despite the wealth of data demonstrating their physiological benefits, the putative high-affinity receptor that mediates these effects ... and N-arachidonoyl serotonin (NA5HT), are TRPV1 ligands.

IGC-AD1 acts as a partial CB1 receptor agonist with anti-neuroinflammatory properties, targeting key pathways involved in neuroinflammation, oxidative stress, and neurotransmitter imbalances.