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C&EN3d
Development of a Multikilogram Synthesis of a Chiral Epoxide Precursor to a CCR1 Antagonist. Use of in Situ Monitoring for Informed Optimisation via Fragile Intermediates ...
The optimisation and scale up of a manufacturing route to a key intermediate, acetic acid 4-acetylamino-3-(2-methyl-oxiranylmethoxy)phenyl ester (2), utilising a SNAr coupling, the hydrogenation of a ...
C&EN16d
Ubiquitin Conjugation Probed by Inflammation in Myeloid-Derived Suppressor Cell Extracellular Vesicles | Journal of Proteome Research - ACS Publications
Ubiquitinated proteins carried by the extracellular vesicles (EV) released by myeloid-derived suppressor cells (MDSC) have been investigated using proteomic strategies to examine the effect of ...
Frontiers19d
Elevated Siglec-7 expression correlates with adverse clinicopathological, immunological, and therapeutic response signatures in breast cancer patients - Frontiers
Furthermore, MDSCs from glioma patients displayed Siglec-7 expression, suggesting its potential role in MDSC-mediated immunosuppression within the glioma tumor microenvironment . In multiple myeloma ...
ascopubs.org28d
SOX30-mediated activation of CXCL2 as promotor of PMN-MDSC recruitment and immunosuppressive microenvironment in TNBC. | Journal of Clinical Oncology - ASCO Publications
SOX30-mediated activation of CXCL2 as promotor of PMN-MDSC recruitment and immunosuppressive microenvironment in TNBC. Authors: Na Sun, Zhenyu Wu, Rui Fu, Pingping Gao, Yuqin Zhou, Tingting Zhao, ...