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CRISPRi Inspired Virtual Lab “CREME”, Set to Lower the Threshold for Major Breakthroughs
something we explored in depth in “Sickle Cell Disease Gene Therapies Approved by FDA Highlighting Potential of CRISPR/Cas9 Technologies”. Since its discovery, finding how to leverage CRISPR to modify ...
The EMBO Journal1d
A shorter splicing isoform antagonizes ZBP1 to modulate cell death and inflammatory responses
Mice express full-length protein ZBP1-L as well as an alternatively-spliced shorter isoform (ZBP1-S) containing only its two ...
Down 21% This Year, Is CRISPR Therapeutics Stock Still a Buy?
CRISPR Therapeutics' first therapy is called Casgevy. It treats sickle cell disease (SCD) and beta thalassemia, both rare inherited illnesses that affect the function of a person's red blood cells. It ...
News Medical1d
Asimov launches AAV Edge, a suite of AI models, host cells, and genetic tools for end-to-end gene therapy development
Asimov, the synthetic biology company advancing the design and production of therapeutics, today announced the launch of the AAV Edge System, a comprehensive suite of tools for adeno-associated viral ...
eLife3d
Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells
Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK ...
eLife3d
Reactive oxygen species suppress phagocyte surveillance by oxidizing cytoskeletal regulators
These cells deploy complex cytoskeletal rearrangements to recognize and eliminate potential threats 3. Even in the steady state, myeloid cells constantly survey their surroundings for potential ...