CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

Advancements in chimeric antigen receptor engineered T-cell (CAR-T) therapy have revolutionized treatment for several cancer types over the past decade. Despite this success, obstacles including the ...

Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital and, Harvard Medical School, Boston, Massachusetts 02139, United States ...

WU-CART-007 is an allogeneic, off-the-shelf, fratricide-resistant CD7-targeted CAR-T cell therapy engineered to overcome the technological challenges of harnessing CAR-T cells to treat CD7+ ...

This week, Aldi shelves stocked a toy shopping cart that has shoppers excited. It features the same chain locking mechanism as the real thing, and comes with a pouch that holds a toy quarter.

Exploration of dsRNA interactome using the K1 antibody and functional studies using CRISPR-Cas9 knockout screening of these dsRBP candidates elucidate the role of dsRNA interactome in immune ...

Engineering Research Center of Ministry of Education on Food Synthetic Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, China Science Center for Future Foods, Jiangnan ...

Using CRISPR-Cas9 targeting multiple cancer-specific mutations, we developed an innovative approach called cancer-specific insertions and deletions attacker that can induce targeted cancer cell death ...

The RNA-guided CRISPR/Cas9 system is a powerful tool for genome editing, but its targeting scope is limited by the protospacer-adjacent motif (PAM). To expand the ...

With an attempt to enhance CAR T cells using CRISPR/Cas9, Tang et al. managed to knock down TGFBR2 and to improve the in vivo CAR T cells in an animal model (65). Cancer, which is a complex disease ...