Our objective was to develop the first in vitro phenotypic screening assay capable of assessing this activation process. Methods: Human primary lung fibroblasts were co-cultured with highly invasive ...

Consequently, a plethora of assays has been developed to provide information about target engagement on isolated proteins and in cells. These techniques monitor changes in stability, structure, ...

State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, Department of Pulmonary and Critical Care Medicine, Targeted Tracer Research and Development ...