Conclusions: The tissue-specific downregulation of glutaminase isoforms—GLS1 in kidney and brain cancers, GLS2 in liver cancer—highlights an adaptive mechanism in cancer cells to limit glutamine ...

From birth to gene-edited in 6 months: Custom therapy breaks speed limits The N-of-1 accomplishment provides a template for swift, personalized genetic therapies.

Base editors can correct disease-causing genetic variants. After a neonate had received a diagnosis of severe carbamoyl-phosphate synthetase 1 deficiency, a disease with an estimated 50% mortality ...

Adenosine deamination drives tip organizer development A crucial evidence supporting that adenosine deamination is singularly responsible for the rescue of mound arrest comes from experiments where ...

A Ludwig Cancer Research study has punctured a longstanding assumption about the source of the most common type of DNA mutation seen in the genome—one that contributes to many genetic diseases, ...

Keywords: stomach adenocarcinoma, DNA cytosine deamination, hotspots, Somatic Copy Number Alterations, CCLE database, TCGA database Citation: Shi Y and Shen H (2023) DNA cytosine deamination is ...

Researchers developed a WGS method that read four canonical DNA bases, viz., adenine (A), cytosine (C), guanine (G), and thymine (T) plus 5mC and 5hmC, epigenetic variants of unmodified C to yield ...

Model for how cytosine deamination, base excision repair, and Mlh1-Mlh3 cleavage cooperate to cause R-loop–induced CAG repeat fragility and contractions. Transcription through the CAG repeat promotes ...

Deletion of yeast cytosine deaminase Fcy1 significantly decreased the rate of CAG repeat fragility and contractions in the rnh1Δrnh201Δ background, indicating that Fcy1-mediated deamination is one ...