Neurotrophins exert their effects by binding to specific receptors on the surface of neurons, triggering signalling pathways that promote cell survival, growth, and differentiation. Although essential ...

About Neurotransmitter Modulators and Sepranolone Sepranolone (isoallopregnanolone) is a first in class GAMSA, or GABA A Modulating Steroid Antagonist ... Existing treatments include dopamine D2 ...

Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn Street, Baltimore, Maryland 21201, United States ...

Psilocybin works by binding to and activating serotonin receptors in parts of the brain, such as the prefrontal cortex and amygdala. These parts of the brain affect mood, cognition, and perception.

In the study, "GluA2-containing AMPA receptors form a continuum of Ca²⁺-permeable channels," published in Nature, researchers used electrophysiology and calcium imaging techniques to analyze ...

We have had a focus on the serotonin system, but are performing studies also on the GABA and Glutamate systems. The development of molecular imaging analysis and statistics is an integrated part of ...

These alterations co-localized with the distribution of serotonin (5-HT1b and 5-HT2a) and γ-aminobutyric acid type A (GABAa) receptors, the norepinephrine transporter (NET), and their encoding mRNA ...

γ-aminobutyric acid (GABA), whether it be lower levels of GABA or the receptor it binds to. But a study published last week (October 3) in Science Translational Medicine, which zeroed in on GABA ...

Here we show that conditional knockout (cKO) mice lacking estrogen receptor α (ERα) in oviduct and uterine epithelial cells have impaired fertilization due to a dramatic reduction in sperm migration.