When it comes to fitness, most people focus on macros, supplements, and training intensity—but there’s a crucial molec ...

While this research focused on αKGDH, other enzymes within the TCA cycle may also be affected, necessitating further investigation. Beyond their immediate findings, the researchers’ use of ...

The evolution of low-temperature adapted enzymes Scientists uncover how enzymes evolved to function at low temperatures by reconstructing prehistoric proteins from extinct bacteria Date: March 25 ...

All experiments with glycyl radical enzymes or activator enzymes were performed in a VAC Atmospheres glovebox (<2 ppm of O 2), unless otherwise described. We activated PFL photochemically by mixing 25 ...

It occurs when intracellular copper binds to proteins involved in the tricarboxylic acid (TCA) cycle, leading to protein aggregation, mitochondrial dysfunction, and ultimately, cell death.

ADP-ribosyl transferases (ARTs) are a family of enzymes which catalyze the addition of a chain (PARylation) or a single moiety (MARylation) of ADP-ribose to their substrates. PARP7 is a ...

In the past two decades, iron and 2-oxoglutarate dependent (Fe/2OG) enzymes have been discovered to catalyze an ever-growing array of novel oxidative modifications of small molecules, thereby ...

The paper addresses an important unresolved mechanism of antibiotic resistance caused by a RNA-modifying enzyme Cfr, a protein that confers resistance to multiple ribosome-targeting antibiotics due to ...

2020). However, investigations into the specific alterations in glycolysis, TCA Cycle, OXPHOS, and PPP in LGG and GBM patients remain limited. In this study, we investigated the expression level of ...

Additionally, the majority of detected abundances for photosystem subunits were negatively associated with light level, while TCA cycle enzyme abundances appeared to be largely unaffected ...