When it comes to fitness, most people focus on macros, supplements, and training intensity—but there’s a crucial molec ...

While this research focused on αKGDH, other enzymes within the TCA cycle may also be affected, necessitating further investigation. Beyond their immediate findings, the researchers’ use of ...

Now, a new study from Scripps Research demonstrates a proof of concept for a new strategy: engineering proteases—enzymes that cut proteins at specific sites—to selectively degrade these ...

All experiments with glycyl radical enzymes or activator enzymes were performed in a VAC Atmospheres glovebox (<2 ppm of O 2), unless otherwise described. We activated PFL photochemically by mixing 25 ...

It occurs when intracellular copper binds to proteins involved in the tricarboxylic acid (TCA) cycle, leading to protein aggregation, mitochondrial dysfunction, and ultimately, cell death.

ADP-ribosyl transferases (ARTs) are a family of enzymes which catalyze the addition of a chain (PARylation) or a single moiety (MARylation) of ADP-ribose to their substrates. PARP7 is a ...