Folate receptors (FR) are the glycoprotein-based receptors in the 38–45 kDa molecular weight range. Folate receptors (FRα, FRβ, FRγ, and FRδ) are cysteine-rich cell-surface glycoproteins that bind ...

In 50 kidney transplant recipients, GLP-1 receptor agonist use led to a mean weight loss of 3 kg, a mean improvement in estimated glomerular filtration rate of 3·5 mL/min per 1·73 m 2, a median ...

G protein-coupled receptors (GPCRs), the largest family of membrane proteins, serve as primary targets for over 30% of FDA-approved drugs. While signaling bias among Gα subtypes is well characterized, ...

Vepdegestrant, a PROTAC estrogen receptor (ER) degrader, vs fulvestrant in ER-positive/human epidermal growth factor receptor 2 (HER2)–negative advanced breast cancer: Results of the global, ...

Interestingly, MmMYL3 is not the first myosin protein to be identified as a viral receptor. Previous studies have shown that non-muscle myosin IIA acts as a receptor for herpes simplex virus (Arii et ...

NR1D2 (nuclear receptor subfamily 1 group D member 2) encodes the mammalian ortholog of E75 and belongs to the nuclear hormone receptor family. We have previously demonstrated that depleting NR1D2 ...

Vepdegestrant is an oral proteolysis-targeting chimera (PROTAC) estrogen receptor (ER) degrader that directly harnesses the ubiquitin–proteasome system.In this phase 3, open-label, randomized ...

But all opioid receptors are not the same. In the current study, the researchers targeted KOR, a subtype of opioid receptor that when activated can decrease synaptic dopamine levels by decreasing ...

Discover how bitter taste receptors in the intestines affect aging. A new study identifies specific receptors linked to metabolic changes, inflammation, and lipid metabolism. Learn how these ...

Hundreds of leucine-rich repeat receptor kinases (LRR-RKs) have evolved to control diverse processes of growth, development, and immunity in plants; the mechanisms that link LRRRKs to distinct ...

Hundreds of leucine-rich repeat receptor kinases (LRR-RKs) have evolved to control diverse processes of growth, development and immunity in plants, but the mechanisms that link LRR-RKs to distinct ...