MDA5 is a critical cytoplasmic RNA sensor capable of triggering type I interferon pathways. This study shows that the E3 ...

34 By modeling the protein, the ligand, and the solvent at the atomistic level, they observed that in the presence of the small molecule, disordered amyloid-β adopted less hydrophobic conformations, ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and ...

A ligand is an ion or small molecule that binds ... or the iron-containing blood-protein haemoglobin. Luminescent aluminum compounds have been utilized for emitting and electron transporting ...

As of 1:09 PM EDT. Market Open. JUPITER, Fla., September 06, 2024--Ligand Pharmaceuticals Incorporated (Nasdaq: LGND) today announced that its partner Travere Therapeutics, Inc. (Nasdaq ...

The accuracy of haemoglobin concentration measurements is crucial for deriving global anaemia prevalence estimates and monitoring anaemia reduction strategies. In this analysis, we examined and ...

With the ultimate goal being the development of a reliable workflow for identifying protein-ligand interactions on a proteome-wide scale, we first sought to explore the impact of increasing ...

Here we show that cobinding of a synthetic ligand to the orthosteric pocket can push natural and endogenous PPARγ ligands (fatty acids) out of the orthosteric pocket towards an alternate ...

and soluble Fas ligand (a mediator of apoptosis) were also observed. Iron deficiency may also play an important role in this anemia because improvement in CHF has been seen with IV iron treatment ...