As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

This excessive deposition disrupts the normal liver architecture and function, contributing to ... in the Fibrogenic ...

When TGF-β is converted from its biologically inactive form (LTGF-β) to its active form (TGF-β), it promotes fibrosis by activating hepatic stellate cells (HSCs). These cells transform into ...

In the liver, HepaStem cells exert a number of different effects: ‘cooling down’the proinflammatory environment of the diseased liver, inhibiting further hepatic stellate cell activation and ...

Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells orchestrate an array of changes including degradation of the normal ECM of liver ...