Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells orchestrate an array of changes including degradation of the normal ECM of liver ...
ECM can directly influence the function of surrounding cells through interaction with cell surface receptors, including integrins and nonintegrin matrix receptors (such as discoidin domain ...
az.vub.ac.be Accumulating evidence suggests that stellate cells are involved in the regulation of the liver microcirculation and portal hypertension. Activated hepatic stellate cells have the ...
jpi{at}soton.ac.uk BACKGROUND Activated hepatic stellate cells (HSC) are central to the pathogenesis of liver fibrosis, both as a source of fibrillar collagens that characterise fibrosis and matrix ...
A guardian molecule ensures that liver cells do not lose their identity. This has been discovered by researchers from the ...
Gene editing is already being used to treat a handful of rare genetic diseases; however, most therapies involve breaking or ...
Gene editing is already being used to treat a handful of rare genetic diseases; however, most therapies involve breaking or ...
Fast Track Designation highlights potential of amezalpat to address unmet need for patients with HCCAmezalpat builds momentum with both ...
Changes to the intermediate filament (IF) protein, vimentin, were found to promote tumor growth by increasing cancer stemness in an oestrogen independent manner. Targeting vimentin and/or the long ...
A recent study reveals that age plays a significant role in the outcomes of intermittent fasting. Researchers discovered that chronic intermittent fasting disrupted the development of ...
Many cells in multicellular organisms are specialised. They have specific roles in the organism of which they are part. Their structure is adapted to their function. They are often grouped ...
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