The original methods for targeting the IGF-I receptor in experimental animals were antisense strategies and dominant-negative mutants of the receptor. They are obsolete. Several antibodies to the ...

Although IR-B is a specific receptor for insulin, IR-A also binds IGF-2 and at lower affinity IGF-1, and may induce biologic effects in response to both IGFs. Second, overexpressed IR enhances the ...

The percentage of cells positive for IGF-1R ranged from 0 to 90 % ( 5 had 0%, 19 had > 10% and 17 had ≥ 50%), median 70%. Of the 17 patients with 50% or more cells positive for IGF-1R; 8 had extensive ...

Male and female mice in which the receptor for insulin had been deleted displayed normal timing of puberty and fertility, but male and female mice with the receptor for IGF-1 deleted showed ...

A new Joslin-led study has identified the insulin receptor as an important protein that promotes islet cell growth in mice ... a protein that mediates the action of insulin, and IGF-1 receptor, ...

A growth hormone called insulin-like growth factor-1 (IGF-1) is likely to play a role in the development of breast cancer, according to two complementary studies published in Annals of Oncology.

Vitamin D and insulin-like growth factor-1 (IGF-1) are involved in a complex interplay that may have implications for growth hormone dosing, researchers found.

However, studies of IGF-1–receptor binding and the metabolic and mitogenic potencies of insulin glargine indicated that there was an increase in both IGF-1–receptor affinity and mitogenic ...

The gene for the IGF-I receptor (IGF-IR) is homologous to the insulin receptor gene in terms of both exon and intron organization and its amino acid sequence (more than 50 percent identical). 1 ...

The type 1 insulin-like growth factor I (IGF-IR) receptor plays a significant role in the growth of normal and abnormal cells, and antibodies against the IGF-IR are now in clinical trials.