PIM protein kinases have been known for some time as oncogenes that promote lymphomagenesis together with MYC (c-Myc). It is now reported that PIM1 is a coactivator of MYC, and it phosphorylates ...

Here, we describe the discovery of novel WDR5 inhibitors for the other WBM (WDR5 binding motif) pocket on this scaffold protein, to disrupt WDR5 interaction with its binding partner MYC by ...

1 School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China 2 The Beibei Affiliated Hospital of Chongqing Medical University, The Ninth People’s Hospital of ...

At the crux of this discovery is the link between MYC and the metabolic processes that maintain balance within our cells, a state called redox homeostasis. For a while now, science has been privy ...

The research was published on Chemical Biology & Drug Design. The MYC protein is a well-established driver in up to 70% of human cancers, but has long been considered “undruggable” due to the ...

School of Chemistry and Materials Science, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, PR China State Key Laboratory of Fire Science, University of Science and ...

The membranes were incubated overnight at 4°C with antibodies against Actin (Proteintech, Cat# 20536-1-AP, 1:3000), HK2 (Cat# 22029-1-AP, 1:2000), LDHA (Cat# 19987-1-AP, 1:2000), PKM2 (Cat# 15822-1-AP ...