In a year where clear frontrunners have been slow to emerge, the Golden Globes offered crucial hints about which films and performances might emerge to lead awards season. Demi Moore appears to be the new best actress frontrunner after her win for "The Substance" in the best actress in a musical or comedy feature category.

The 2025 Golden Globes marks Moore’s first Golden Globes nod since 1997 for the thriller drama, “If These Walls Could Talk.” This time, she was nominated for Best Performance by a Female Actor in a Motion Picture – Musical or Comedy for the horror sci-fi film “The Substance.”

“I’ve been doing this for 45 years, and this is the first time I’ve ever won anything as an actor,” Moore said of her win for “The Substance.” The roar that shook the Golden Globes when Demi Moore took the stage could probably be heard across state lines.