Genes regulating the finger-like cellular protrusions—filopodia have long been implicated in cancer metastasis. However, depleting the flat lamellipodia but retaining filopodia drastically hampers ...

Department of Surface Engineering, Jožef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia Laboratory of Physics, Faculty of Electrical Engineering, University of Ljubljana, Tržaška 25, SI-1000 ...

Now, two independent studies have honed in on inflammatory microglia as a potential therapeutic strategy. In mice, induction of T regulatory (T reg) cells or supplementation with a metabolic ...

Credit: Northwestern University But not all microglia are created equal. Some are quite effective at removing plaques, while others struggle, the study found. Also, microglia in treated brains adopt ...

In the early stage of photoreceptor differentiation in zebrafish, cone photoreceptors were reported to extend thin projections called filopodia from their apical regions; however, their ...

allowing it to modulate B-lymphocytes and disease-associated microglia within the CNS. This mechanism is believed to address the underlying pathology of progressive MS by targeting the inflammatory ...

Previous studies have identified potential targets, but they were mainly found in non-nerve cells, such as microglia. Our discovery, however, focuses on a membrane protein located on the surface of ...

This inflammation is partly down to immune cells called microglia. In the brains of the treated mice, some microglia switched from attack (a mode known as M1) to a more neutral state (M2). This ...

He recently used brain tissue preserved from an old amyloid study to learn how immune cells called microglia can clear those plaques and then switch to helping the brain heal, possible clues for ...

In the present study, via the condition knockout strategy to generate mosaic microglia population in adult zebrafish and mice, we revealed that the turnover and maintenance of microglia is ...