A new study in Nature Aging reveals how nucleolar enlargement can act as a biological “timer” that drives catastrophic genome ...

Ricin is a ribosome inactivating protein that catalytically removes a universally conserved adenine from the α-sarcin/ricin loop (SRL) of the 28S rRNA. We recently showed that ricin A chain (RTA) ...

In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis.The core event in this pathway ...

The ribosome consists of two ribonucleoprotein subunits. The small subunit mediates the interactions between the anticodons of the tRNAs and the codons in the mRNA that they are translating to ...

Nucleus defends that its method can be used to determine an individual’s risk. The spokesperson pointed us to a 2018 paper where the authors said they had developed validated methods for five ...

Poxvirus alters host ribosome function to prioritize viral protein synthesis, inducing structural changes in the 40S subunit and utilizing factors such as RACK1 and eIF3.

Nonviral delivery of nucleic acids to the cell nucleus typically requires chemical methods that do not guarantee specific delivery (e.g., transfection agent) or physical methods that may require ...