Colorectal cancer (CRC), a type of cancer that affects the large intestine and rectum, is one of the leading causes of cancer ...

A recent high-throughput study shows that some types of cancer are associated with mutations in a specific proto-oncogene or in a specific pair of proto-oncogenes (Thomas et al., 2007).

Gene sequencing studies have uncovered mutations in key oncogenes responsible for colorectal cancer (CRC) development. CRC ...

For instance, one 2016 study reported that a handful of synonymous mutations in the KRAS oncogene changed a rare glycine-encoding codon into a commonly used one, potentially accelerating translation.

Researchers from Fujita Health University, Japan, uncover specific gene mutations and mechanisms that may contribute to the ...

Our validation studies revealed mutations in most of the oncogenes analyzed, and the mutation frequency was consistent with previous reports. We also found new low-frequency mutations in our tumor ...

Researchers used mutational analysis to identify gene mutations that may drive carcinogenesis in colorectal tumors with high ...

Operationally, mutated proteins that induce the development of the leukemic phenotype (oncogenes ... Additional examples are the mutations detected in the kinase growth factor receptors Kit ...

Bacteria could be engineered to detect and respond appropriately to various oncogenic mutations, or even difficult-to-treat infections like Clostridium difficile. Worthley sees this potential to marry ...

tumors with high tumor mutation burden that lack mutations in the major oncogenes. Their findings highlight alternate site-specific mechanisms of CRC development that can guide treatment selection ...