A new mechanism has been identified by scientists from the Wistar Institute in Philadelphia and The Vienna Biocenter in Austria that is involved in normal repression of the p53 protein which is ...

One such mechanism involves a protein called p53. Often dubbed the "guardian of the genome," this protein plays a pivotal role in ensuring that your cells grow, divide and die in an orderly fashion.

Currently, we have already known some mechanisms of how TAMs can inhibit the antitumor activity of T cells. Nevertheless, how p53 modulates TIME is still elusive. Researchers found that the loss ...

In addition, p53 is a master sensor of damage that triggers repair and defence responses. As discussed below, there is evidence indicating that those mechanisms or interventions that decrease ROS ...

M. Kaldmäe et al., “A ‘spindle and thread’ mechanism unblocks p53 translation by modulating N-terminal disorder,” Structure, 30: 733–42, 2022.

Ubiquitin-specific proteases play a critical role in regulating cell death pathways in breast cancer, affecting tumor ...

Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney ...

A new research paper was published in Oncotarget, Volume 16, on February 18, 2025, titled "Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells.