Swift elimination of undesirable cells is an important feature in tumour suppression and immunity. The tumour suppressor p53 and interferon-α and -β (IFN-α/β) are essential for the induction ...

In a paper published in Science Bulletin, researchers developed a selective DNA aptamer-based PROTAC targeting p53-R175H, a common hotspot mutant with dominant-negative and oncogenic activity.

The three co-primary comparisons for the endpoint of progression-free survival (PFS) were between arms A and B in p53 mut, p53 wt, and the entire trial population, each at a p=0.02. The sample size ...

They discovered the mechanism by which p53 is inactivated in cancerous cells, allowing tumors to grow. Skip to main content. Your source for the latest research news. Follow: ...

Constitutive activation of the tumor suppressor p53 in hepatocytes paradoxically promotes non-cell autonomous liver carcinogenesis.. Cancer Research , 2022; DOI: 10.1158/0008-5472.CAN-21-4390 Cite ...

The p53 gene is involved in repair of DNA damage and, if the damage is too great, causing a mutated cell to die before it can cause further problems, up to and including cancer.

The 41 children who had tumors that exhibited neither overexpression of p53 nor mutations in TP53 had a mean rate of progression-free survival at five years of 46±8 percent, as compared with 41± ...

A new research paper was published in Oncotarget, Volume 16, on February 18, 2025, titled "Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells." ...

The p53 protein variant Δ133p53α may play an important role in improving the effectiveness of chimeric antigen receptor (CAR) T cell therapy. genprowebdirectory Facebook Linkedin RSS Twitter Youtube ...