News

MedPage Today on MSN4d
Adding Neoadjuvant Nivolumab to Chemo Improved Survival in Resectable NSCLC
Neoadjuvant nivolumab (Opdivo) plus chemotherapy significantly improved overall survival (OS) compared with chemotherapy ...
C&EN6d
Phosphoramidate Dinucleosides as Hepatitis C Virus Polymerase Inhibitors
Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS—Université Montpellier 1—Université Montpellier 2, Place Eugène Bataillon, CC1704, 34095 Montpellier Cedex 5, France, Department of ...
SciELO7d
Faecal examination and PCR to detect Strongyloides venezuelensis in experimentally infected Lewis rats
The findings of Oikarinen et al. (2009) support this hypothesis. These authors demonstrated that PCR inhibitors are relatively common in stool samples and that they can strongly influence the results ...
Frontiers17d
Development and application of a highly sensitive quadruple droplet digital PCR method for simultaneous quantification of sulfonamide resistance genes
To overcome this limitation, a quadruple method was established by integrating droplet digital PCR (ddPCR) with the ratio-based probe-mixing strategy, achieving sensitive detection of sul1, sul2, sul3 ...
C&EN20d
Trihydroxybenzaldoximes are Redox Cycling Inhibitors of ThDP-Dependent DXP Synthase
Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States Chemistry-Biology Interface Graduate Training Program, Johns ...
ascopubs.org21d
Efficacy and safety results from ASCEMBL, a phase 3 study of asciminib versus bosutinib (BOS) in patients (pts) with chronic myeloid leukemia in chronic phase (CML-CP) after ...
Rusfertide (PTG-300) treatment in phlebotomy-dependent polycythemia vera patients. Overall survival by IDH2 mutant allele (R140 or R172) in patients with late-stage mutant-IDH2 relapsed or refractory ...
Frontiers24d
Environmentally Persistent Free Radicals lead to selective inhibition of CYP1 monooxygenase activities, and increased production of reactive oxygen species by reaction uncoupling
Despite the inhibition of substrate metabolism, each CYP1 enzyme, when reconstituted with NADPH-cytochrome P450 reductase (POR) was able to synergistically stimulate the generation of reactive oxygen ...