A research team led by Andrea Eveland, PhD, associate member at the Donald Danforth Plant Science Center, has uncovered key genetic regulatory factors that control pleiotropy—a phenomenon where a ...

Local genetic correlations were analyzed using HESS software, and pleiotropy analysis identified shared genetic loci in brain tissues. Hyprcoloc analysis was used to explore shared genetic factors ...

Robustness of the results was assessed through sensitivity analyses, including the “leave-one-out” approach and tests for potential pleiotropy. Results: The MR analysis provided substantial evidence ...

We suggest that paralogs can overcome the obstacle of structural pleiotropy by regulatory evolution at the transcriptional and post-translational levels. Mutations in paralogous proteins originating ...