A degrader molecule, either PROTAC or molecular glue, brings the protein of interest (POI) and E3 ubiquitin ligase in close proximity and engages the ubiquitin-proteasome system (UPS), the cellular ...

Bacterial genomics is a scientific discipline that concerns the genome, encompassing the entire hereditary information, of bacteria. Bacterial genomics can, for example, be used to study bacterial ...

"By transforming questions about metabolism into a genomics challenge, we were able to draw a 'wiring map' of adult worm metabolism that revealed numerous novel insights." "The most exciting part ...

Imagine an AI system capable of guiding a robot to manipulate physical objects as effortlessly as it navigates software menus. Such seamless integration of digital and physical tasks has long been the ...

GameSpot may get a commission from retail offers. Last year, Activision confirmed that Call of Duty: Warzone's original Verdansk map would return to the free-to-play battle royale in 2025, but the ...

Hospitals in England have been hit by a storm of norovirus infections as the number of beds taken up by patients with the virus reached a record high last week. An average 1,160 patients a day were in ...

Until recently, decoding these complex genetic blueprints was beyond scientists’ reach. Now, thanks to advances in sequencing technologies, the plant genomics field is flourishing. With the ability to ...

Our results show the importance of the dynamic features in protein structure and how the linker region of a PROTAC may contribute to protein motions to achieve PROTAC-mediated POI degradation.

The Price to Earnings (P/E) ratio, a key valuation measure, is calculated by dividing the stock's most recent closing price by the sum of the diluted earnings per share from continuing operations ...

Premature ovarian insufficiency (POI) is the loss of normal ovarian function before the age of 40 years, a condition that affects approximately 1% of women under 40 years old and 0.1% of women under ...