The researchers identified the structure of this machine, the mitochondrial pyruvate carrier (MPC), and 50 years since its discovery, have shown how it operates like the lock on a canal to transport ...

Your body produces the enzyme creatine kinase (CK) or creatine phosphokinase to keep your muscles functioning properly. Healthcare providers use the CK test to check levels of this protein in your ...

Our study identified protective metabolites linked to glycolysis and mitochondrial function, suggesting important pathophysiology in glaucoma. One of these metabolites of significance is pyruvate.

Researchers from Tohoku University challenged the mouse brain with a metabolic load induced by epileptic seizures, and observed fluctuations in blood volume, astrocytic pyruvate, and neuronal ATP.

FAA1, fatty acyl-CoA synthase; ZWF1, glucose-6-phosphate dehydrogenase; PFK, 6-phosphofructokinase; PYK, pyruvate kinase; PYC1, pyruvate carboxylase ... carbon source for the lipid synthesis when ...

This crystal structure of nearly full-length human cGMP-dependent protein kinase Iβ (PKG Iβ) provides convincing new insights into how in the absence of cGMP the activity of the catalytic domain is ...

Hepatocellular carcinoma (HCC) is a deadly tumor with high heterogeneity. Aerobic glycolysis is a common indicator of tumor growth and plays a key role in tumorigenesis. Heterogeneity in distinct ...