In a landmark discovery, researchers have unveiled the highly dynamic and adaptable architecture of the mammalian pyruvate ...

The AMP-activated protein kinase (AMPK) system acts as a sensor of cellular energy status that is conserved in all eukaryotic cells. It is activated by increases in the cellular AMP:ATP ratio caused ...

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CAMBRIDGE, Mass., May 14, 2025 (GLOBE NEWSWIRE) -- Agios Pharmaceuticals, Inc. (Nasdaq: AGIO), a leader in cellular metabolism and pyruvate kinase (PK) activation pioneering therapies for rare ...

These data suggest that JMJD8 controls glycolysis and respiration of ECs ... JMJD8-interacting proteins with known functions in cellular metabolism like pyruvate kinase M2. Knockdown of Jmjd8 ...

Glycolysis not only supports ATP production but also provides ... Similarly, in glioblastoma stem cells, ALDH1A3-driven pyruvate kinase activation promotes XRCC1 lactylation-mediated DNA repair and ...

The research she presented focused on neovascular age-related macular degeneration (AMD). "This is actually the first phase 2 study looking at a tyrosine kinase inhibitor for wet AMD," Dr. Talcott ...

Functional studies demonstrated that DTL promoted breast cancer cell proliferation and migration in vitro through glycolysis remodeling. Mechanistically, DTL positively regulated key glycolytic ...